After reading
this article, I'm thinking that all kinds of brain problems could be caused by a combination of infections and drawing the genetic short straw, which is why some people have these problems and some don't, even in the same family.
The problem is, a lot of the time there seems to be finger pointing, such as when it's stated that people with depression are more likely to develop Alzheimer's disease. There is this attitude that if you just stop being depressed (wow, wouldn't that be nice) you'll become less prone to Alzheimer's disease, so pull yourself up by the boot straps, you pudding, and stop being such a Debbie or Donnie Downer.
Well, what if the same genetic trigger is what causes both depression and Alzheimer's in some unlucky people? Also, note that not everyone with a mood disorder ends up with Alzheimer's disease. Correlation is not causation.
According to the article, "it is known that people with a gene called ApoE2 have brains that are good at sweeping out plaque, and have a low risk of Alzheimer’s in old age. Those with a different version, ApoE4, are inefficient in removing plaque and have a high risk of Alzheimer’s."
These men are brothers. The fellow on the left side of your monitor was 57 years old when this picture was taken. The one on the right side of your screen was 59.
The fellow on the left presents as a healthy older adult man. The older brother does not look well, and he isn't. He was diagnosed with dementia two years previously. Before I was aware of this, I surmised that he was either having endocrine problems (hyperthyroidism), or he was developing Parkinson's disease. His facial expression and his stance look similar to those of a person with Parkinson's. I had also seen several photos of him in which he had spilled food or drink on himself, which would be another indicator of neurological problems. We all do it sometimes, but when such occasions become frequent, it's a red flag.
Breaking things down:
Both of these men come from a family that is prone to cancer and cardiovascular disease. Both of their parents died at age 74. (I am unsure of the reason for their deaths.) Their eldest brother died at age 57 from lung cancer. Both of these men developed an addiction to nicotine.
The older brother had more health problems than the younger over the years. He was prone to depression and anxiety, including social anxiety, and developed an addiction to alcohol. He was one of those people who seemed to come down with whatever "bug" was making the rounds. Overall, he seemed to be of less hardy stock than his younger brother, who had no issues with addiction to alcohol or drugs, no issues with major depression, tended to be socially gregarious, and seemed to be in good health most of the time.
It would seem likely that the younger brother possesses the APOe2 gene, where the elder brother drew the short straw and ended up with the APOe4.
My theory is that such a gene may also leave people who have it prone to psychological disorders, which I postulate are also triggered by infections. Someone with "good" genes will be able to fight off such infections and clear the resulting residue from their systems without issue. Someone who drew the genetic short straw will not be similarly blessed.
Viral infections are also theorized to trigger a tendency to obesity in people with a certain genetic code. Obesity gets blamed for everything, but here again, correlation is not causation and if shaming people worked, we would have no addicts, no one with psych disorders, and no fat people. Clearly, shaming people doesn't cure any of the world's ills, so it would be nice if we could stop doing it and instead look for solutions.
TL:DR
Science explains physical anomalies. Go science!
Brain diseases suck and are probably caused by bad microbes and mutated genes.
One bad gene is all it takes to perma-fuck your life.
Look for solutions rather than pointing the Finger of Shame and Blame.
Be compassionate. You never know when it may be your turn to draw the short straw.
Now you know, and knowing is half the battle. Go GI Joe!
(If you weren't a child of the 1980's, you probably won't understand this last reference.)
~The Cheese Hath Grated It and Blinded You With Science~